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Both medications are FDA-approved for type 2 diabetes, carry similar gastrointestinal side effect profiles, and include black-box warnings for thyroid C-cell tumor risk

Particularly for tirzepatide, in the mixed effects model on a subset of the data with therapy duration greater than 180 days, there is a positive coefficient with therapy duration and weight regain after cessation with a significant P value

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Eligibility is determined through provider evaluation

Currently, the only FDA-approved treatment for MASH in people with moderate to severe liver fibrosis is Rezdiffra (resmetirom), which Sun Kim, MD, an associate professor of Endocrinology at Stanford Medicine who wasnt affiliated with the trial, echoed that assessment