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Despite its potent anti-diabetes effects, the clinical application of native GLP-1 is hindered by its rapid clearance by the dipeptidyl peptidase-4 (DPP-4) enzyme in vivo, resulting in a half-life of only 2 minutes [17, 18]

Double dosing does not recover lost weight loss and increases your risk of severe nausea, vomiting, and gastrointestinal side effects

Individual results vary: some patients lose 20% or more, while others achieve 810%

Now you might wonder, "What makes each GLP-1 different, and which is right for me?" That must be a discussion between you and your doctor, as a 2021 review 7 tells us the most notable differences between GLP-1 receptor agonistslike pharmacokinetics 8 (how the body interacts with the medication), dosing frequency, and administrationcan impact the GLP-1 RA's efficacy, tolerability, and patient satisfaction

Some patients feel increased hunger or cravings late in the week before their next injection

0.2%, p = 0.02), 3 years (0.2% vs