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Bariatric surgery--which seeks to reduce the size of the stomach or bypass part of the GI tract--was conceived in the 1960s when surgeons observed that gastric cancer patients who had part of the stomach removed (subtotal gastrectomy) went on to lose weight

This makes it a particularly logical addition for people transitioning off tirzepatide or semaglutide who want to maintain some GLP-1 pathway support without the full potency and cost of injectable GLP-1 agonists

[34] [35] In the brain, they act on satiety centers to reduce appetite and food intake

There is some consensus that obesity is a chronic condition that must be managed, and not cured, and thus miracle drugs such as Wegovy may be sending the wrong message to individuals struggling with their weight

Berdahl JP, Fleischman D, Zaydlarova J, Stinnett S, Allingham RR, Fautsch MP

10.1016/j.molmet.2020.101090 [DOI] [PMC free article] [PubMed] [Google Scholar] 90