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First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin
When used as a medication, these drugs can help lower blood sugar levels, reduce appetite, and promote weight loss, making them especially beneficial for individuals with type 2 diabetes and those looking to lose weight
The breakthrough came from recognizing that the three hormones balance each other
The newer dual-action agent tirzepatide (Mounjaro) targets both GLP-1 and GIP receptors and is licensed in the UK for type 2 diabetes management
One was a mature glucagon and the other was called the proglucagon fragment
