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Multidistrict litigation (MDL) is a federal legal procedure that consolidates similar lawsuits from various districts into one court for pretrial proceedings

Increasing evidence from immunometabolic research supports a bidirectional relationship between metabolic dysfunction and inflammatory arthritis, whereby chronic inflammation promotes insulin resistance, which in turn amplifies synovial and entheseal inflammation (28)

Mayendraraj, A., Rosenkilde, M

Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders

Asp9 and Asp15, which are amino acids that precede both fragments respectively, and as mentioned are susceptible to hydrolytic cleavage, are considered unmodifiable amino acid positions due to incurred loss in potency [29]