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It should be noted that these findings do not imply that DPP-4 inhibitors are harmful in any way or that GLP-1 drugs are definitely beneficial for brain health. Kornelius also noted that tirzepatide, a dual GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist, was not evaluated since it was approved after the beginning of the study period.

24 This can be due to differences in the specific drug used, the dosage, the duration of the study, the characteristics of the participants (age, baseline health) 9 , the methods used to measure body composition (DXA, BIA, MRI all have different strengths and weaknesses) 16 , and whether interventions like dietary counseling (especially protein emphasis) and exercise were included

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