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The antihypertensive effects of GLP-1 RAs are due to several mechanisms: natriuretic effects, vasodilation, and reduced sympathetic activity
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As many as 17% of the adult population will have positive findings from the dipstick test
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Similarly, in Agpat2 / genetic models of lipodystrophy, leptin enhanced insulin sensitivity and alleviated steatosis largely independent of hepatic leptin receptor signaling, suggesting a peripheral mechanism (33)
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