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Retatrutide is an investigational GLP-1, GIP, and glucagon triple receptor agonist not yet licensed by the MHRA or EMA

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Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol.78 The half-life of PEG-loxenatide is approximately 1 week.123 GLP-1RAs

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