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Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-alpha in mice

A comprehensive meta-analysis of observational cohort studies by Celsa et al

Country Segmental Analysis 16.10.2
In fact, a 2026 large retrospective observational cohort study found no increased acute pancreatitis risk in type 2 diabetes patients using GLP-1RAs
The matched populations were 60% men, aged 61 years and with a diabetes duration of 10 years
This called for further studies investigating modification of the GIP C-terminus on interaction with the GIP receptor