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Typical starting doses include: Semaglutide (Wegovy): 0.25 mg weekly Tirzepatide (Zepbound): 2.5 mg weekly These starting doses were studied in programs such as the STEP and SURMOUNT trials and were gradually increased to achieve validated metabolic outcomes

6 months and beyond : Sustained and more significant weight loss becomes clear
Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial

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[55] Metoclopramide has more CNS adverse effects than domperidone and carries a US FDA boxed warning for tardive dyskinesia, a potentially irreversible condition

Understanding your genetic predispositions helps optimize which medication (semaglutide vs