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The patient should continue semaglutide while initiating first-line RLS treatment with alpha-2-delta ligands (gabapentin, gabapentin enacarbil, or pregabalin...
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In this guideline, we update the pharmacotherapy recommendations in the 2020 Canadian clinical practice ...

Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells that modulates glucose metabolism by controlling insulin excretion and glucagon secretion and inhibits gastric emptying leading to decreased food intake, thus limiting weight gain

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But for many appropriate patients, the benefits of treating obesity far outweigh the risks of doing nothing
