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doi: 10.1042/BST20120236 115 MacDonaldPEWangXXiaFEl-kholyWTargonskyEDTsushimaRGet al

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This dual role underpins the concept of biased agonism, where different ligands selectively favor either G-protein-mediated or -arrestin-mediated signaling, allowing for fine control over therapeutic outcomes and side-effect profiles