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It ranked 90th in 2021, the most recent year for which federal data on hundreds of the most commonly prescribed drugs is available

The medication has been used safely in millions of patients over six decades, providing physicians with extensive data on long-term outcomes and rare adverse effects

It works by mimicking a natural hormone, which helps regulate blood sugar levels and improves insulin secretion

Topiramate is not licensed for weight management in the UK, and any combined use should only occur under specialist medical supervision with careful monitoring of side effects and nutritional status

If you think of it as a short-term tool, then what will likely happen is you will lose the weight, and once you stop taking the medicine, you will regain it

(To understand more about this dynamic, read this investigation WIRED published in 2020 into why the memory supplement Prevagen stayed on the market despite questions about its safety.) Despite several high-profile public health disasters related to supplements, including the herbal stimulant ephedra causing a wave of heart attacks and other adverse effects, regulatory control over the supplement industry remains startlingly laxeven as the market has exploded in popularity