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Unopened pens stored correctly in a refrigerator have a shelf life of three years from manufacture, whilst opened pens remain safe to use for six weeks regardless of storage method
Stimulant laxatives such as senna and bisacodyl should be used sparinglytypically no more than 2-3 times weeklybecause regular use can reduce your colon's natural contractions over time
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Use of these medications on the index date was also an exclusion criterion, with the exception of treatment initiation with semaglutide or DPP4i on the index date in the corresponding study groups
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