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Woerle et al., Empagliflozin reduces body weight and indices of adipose distribution in patients with type 2 diabetes mellitus

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While both medications reduce appetite through different mechanismsphentermine via sympathomimetic stimulation and semaglutide through GLP-1 receptor activationthe combined effect on appetite suppression, cardiovascular parameters, and metabolic function has not been systematically studied in large populations

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Specifically, patients on Tirzepatide lost an average of 22.8 kg (50.3 pounds), compared to 15.0 kg (33.1 pounds) with Semaglutide