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There is, however, recent evidence from mice and humans that GLP-1 secretion from pancreatic - cells and intestinal L cells is increased by the direct action of estrogen on these cells (53)

10.1210/en.2014-1248 Endocrinology 58 RieraC

Geiger et al., 2008

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Constipation and other GI side effects are consistently worse when doses are escalated quickly

Outeirio-Iglesias V, Roman-Prez M, Gonzlez-Matas LC, et al
