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GLP-1 is also implicated in regulating hedonic eating through GLP-1Rs located elsewhere in the brainstem (98100)

While consensus does not exist regarding the exact synergistic mechanisms by which dual-agonists work, the addition of GIP agonism is posited to improve the HbA1c control and weight loss offered by GLP-1 agonists alone by enhancing insulin secretion, decreasing energy consumption, and stimulating satiety in the hypothalamus

Surgery for weight loss in adults

[DOI] [PubMed] [Google Scholar] 58.Cooper ME

Rendell, M