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27 Investigators evaluated the safety, efficacy, and tolerability of three therapies when added to metformin: exenatide (Byetta, Amylin), sitagliptin, and pioglitazone

In studies, participants lost an average of 15% body weight over 68 weeks

Diet Consume foods rich in dietary fibers and proteins and those with a low glycemic index to reduce the risk of side effects

Potential suicide reductions

While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD

This creates a self-reinforcing cycle: low testosterone promotes further fat accumulation, which drives more aromatase conversion, leading to even lower testosterone (Cohen, 1999, Journal of Clinical Endocrinology & Metabolism )