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Rhodes CJ, White MF, Leahy JL, Kahn SE

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By stimulating GLP-1 receptors, GLP-1RAs increase insulin secretion and suppress glucagon release in a glucose-dependent manner, thereby improving clinical and patient-reported outcomes related to glycaemic control and weight

As of March 29, 2026 , retatrutide remains investigational , not FDA approved

-Type 2 diabetes mellitus: Hypoglycemia and hyperglycemia occur more often during pregnancy in patients with pregestational diabetes
