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Semaglutide interacted with circumventricular organs, where GLP-1R expression is abundant, and with regions protected by the BBB (lateral septal nucleus, nucleus tractus solitarius, hypothalamic arcuate nucleus) (136)

The question during this phase shifts from how much weight can I lose to how do I maintain the loss I have achieved

GLP-1 medications offer promising benefits for weight management, but their high costs can be a significant consideration

This is confirmed by the largest published phase 2 trial on retatrutide, which included 338 non-diabetic participants

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Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells