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Prednisone is a prodrug, meaning your liver has to convert it to prednisolone, its active form

Reviews, duplicate publications, isolated case reports, conference abstracts, editorials, and brief communications were excluded

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However, the off-label use remains ethically questionable and the real risk-benefit ratio is still unknown

Some companies are already planning for that future

In various in-vivo and in-vitro studies, exogenous administration of IGF-1 mediated has been shown to increase glucose utilization, release acetylcholine from neurons, activate N-methyl-D-aspartate receptor (NMDA), protect the cerebromicrovascular environment, and maintenance of synaptic structure and function [36, 41,42,43,44,45]