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The reason for this is because there are limited studies on the pathophysiology in children and animal models that fully recapitulate pediatric MASLD/MASH

Notably, while recent progress with co-agonists such as tirzepatide has been impressive, higher doses of semaglutide achieved greater than 15% weight loss in investigational studies of human subjects with obesity, raising the bar for co-agonist efficacy

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433 Specifically, alcohol-dependent rats were administered semaglutide, which resulted in a significant reduction in their alcohol consumption
Tsai, W
