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Declarations Conflict of Interest Stephano Cedirian, Monia Donati, Luca Rapparini, Francesca Pampaloni, Michelangelo La Placa, Rossella Sgarzani, Luca Negosanti, Emanuel Raschi and Michela Starace is an Editorial Board member of Dermatology and Therapy

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Limited human pregnancy data exists for these medications, which is why regulatory bodies and medical societies recommend discontinuation before conception

Minimum between doses: 72 hours Flexibility window: Must maintain 3-day minimum gap Missed dose window: 4 days One day early risk level: Low (as long as 72+ hours maintained) Compounded tirzepatide follows the same rules

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