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Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls

This integrated effect provides a biologically plausible pathway for reducing vulnerability to cognitive decline and neurodegeneration over time

These properties make them an attractive therapeutic option for managing non-alcoholic fatty liver disease (NAFLD), particularly in individuals with concurrent diabetes mellitus and obesity

Contact details: Masao Toyoda MD/PhD, Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes

Based on the TSA, the significant difference in the risk of hospitalization for heart failure between combination therapy and monotherapies with SGLT-2i or GLP-1RA or TAU were true positive differences, and the analysis revealed a sufficient number of participants