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There was a substantial reduction (2.40% with 10-mg tirzepatide, 2.34% with 15-mg tirzepatide, and 0.86% with placebo) of HbA1c from the pretreatment baseline [26]

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The absolute risk reduction demonstrated clinical significance even at 24 months, with the tirzepatide group maintaining consistently lower risk profiles across all outcomes, as illustrated by the negative risk differences favoring tirzepatide treatment (Figure 2)

P., Rosenkilde, M