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[8] [16] In 2023, Huberman's lab, with David Spiegel, published a research paper on stress mitigation and carried out research on cortisol

But like any powerful tool, it requires proper use, oversight, and integration into a holistic plan

Body composition matters more than the number on the scale

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Severe caloric restriction (under 800 to 1000 calories daily for extended periods) while on retatrutide leads to excessive muscle loss, hair shedding , fatigue , nutrient deficiencies, and metabolic adaptation that slows long-term progress

Each comes with its own dosing curve, and researchers who have worked through one titration protocol will find the structure familiar when they approach another