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These results, presented in 2024, provided the first solid evidence that GLP-1 drugs could meaningfully slow Alzheimers in humans

Lillys oral GLP-1 candidate, orforglipron, delivered a 12.4% average body weight reduction in a Phase 3 trial over 72 weeks

"I don't feel like I'm dieting," said Fierstein during a discussion with Page Six

Clinical trials are underway to formally study whether GLP-1 agonists could treat alcohol use disorder, but no medications in this class are currently approved for that purpose

In the intestinal L-cells, proglucagon is cleaved by the enzyme prohormone convertase 1/3 to produce GLP-1, along with other peptides including GLP-2 and glicentin

It will be interesting to see what price the government is able to negotiate with the drug makers as this might help to lower the price of these medications for all Americans, he says