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Seek support: Encourage patients to connect with support groups, friends, or family members who can help them stay motivated and accountable

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Diabetes Obes Metab (2016) 18(3):20316

Health and Wellness: Oral and Injectable Medications for Type 2 Diabetes

Additional preclinical proof of concept came from similar studies in rodent models of T2D and/or obesity wherein the combined activation of both GLP-1R and GIPR resulted in superior glucose-lowering and/or reduction in weight gain compared to the activation of either receptor alone [[78], [79], [80]]

GLP-1 medications work through several complementary mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on appetite centres in the brain , leading to reduced caloric intake and weight loss Commonly prescribed GLP-1 receptor agonists available in the UK include semaglutide (Ozempic, Wegovy, Rybelsus [oral form]), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Byetta, Bydureon)