glp 1 agonist statpearls Harnessing GLP-1 Receptor Agonists for Obesity Treatment: Prospects and Obstacles on the Horizon Glucagon-like peptide-1 receptor agonist use

An Effective Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Improves Sarcopenic Obesity in Obese Mice by Modulating Skeletal Muscle Metabolism

DPP-4 inhibitors are oral and weight-neutral but generally less potent

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doi: 10.1124/pr.108.000604 [DOI] [PMC free article] [PubMed] [Google Scholar] 8

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In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002