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Thats usually a conversation patients have with their doctors, who know a lot about these medications and how they work. Microdosing compounded versions of GLP-1s is different from having a doctor adjust the prescribed dosage of your GLP-1 medication

The 59-year-old from New Jersey got a sneak peek at what it's like to be on this new medication when he participated in an 18-month clinical trial Eli Lilly conducted in 2024 and 2025 to gauge safety and efficacy

Older adults Researchers over 60 may see slightly slower weight loss and face a higher risk of sarcopenia (muscle loss) during treatment

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Furthermore, increased blood-brain barrier permeability permits peripheral pro-inflammatory markers to diffuse in the brain, inducing neuroinflammation

Beyond the pancreas, GLP-1R is expressed in the brain (particularly the hypothalamus, brainstem NTS, and reward circuitry), heart, kidney, lung, gastrointestinal tract, bone, and immune cells