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After trials showed its drugs were successful at treating cardiovascular issues, Novo Nordisk successfully gained approval from the Food and Drug Administration in March to add cardiovascular benefits to Wegovys label

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For severe side effects, please seek in-person medical attention at your local emergency department or urgent care centre

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In 2021, Novo Nordiskwhich also markets the GLP-1 receptor agonist semaglutide as Rybelsus for T2Dlaunched two Phase III trials, EVOKE and EVOKE Plus, studying the drug in approximately 3,700 people with early-stage Alzheimers disease

The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, directly compared tirzepatide with semaglutide