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Description

Alicic, E.J

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GLP-1RA Mechanism of Action GLP-1 (glucagon-like peptide-1) is a hormone secreted by the intestinal tract during feeding, which enhances insulin secretion and inhibits glucagon secretion in a glucose concentration-dependent manner, and delays gastric emptying to reduce the amount of food eaten through central appetite suppression

While it is well-established that intestinal GLP-1 cells can exert influence through paracrine mechanisms, recent evidence suggests the possible existence of synaptic-like connections between GLP-1 cells and peripheral neurons, including those of the vagus nerve

Studies GLP-1 receptor agonists like Wegovy and Ozempic help with weight loss by reducing appetite and slowing digestion, making dietary choices crucial (Kute et al., 2024)