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To be clear, microdosing tirzepatide is considered off-label

Tirzepatide This innovative medication offers dual action by combining GIP and GLP-1 receptor agonists

A separate meta-analysis found semaglutide was also associated with a significantly higher risk of gallbladder-related disorders compared to tirzepatide

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However, a separate 2024 metaanalysis found no significant pooled effect of GLP1RAs on PWV, highlighting heterogeneity across populations, followup duration and measurement methods [39]