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A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation

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Normalizing deficient prandial insulin in -cell GIPR KO mice restored adiposity to control levels, further implicating the insulin stimulatory effect of GIP in this phenomenon as seen in the human data