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Recent Developments: 2025: Eli Lilly received FDA approval for tirzepatide (Zepbound) as a treatment for moderate-to-severe obstructive sleep apnea in adults with obesity the first pharmacotherapy approved for this indication expanding tirzepatide's approved uses beyond metabolic conditions into a respiratory indication affecting over 30 million Americans and supported by SURMOUNT-OSA trial data showing 63% reduction in apnea-hypopnea index

Both GIP and GLP-1 play roles in regulating food intake by stimulating neurons in the brains satiety center

In this perspective, GLP-1RAs may act through all of these different pathways

Ill also give recommendations for those who are taking or are considering taking them for weight loss

As well as physical health risks, the stigma attached to excess body weight and obesity can have adverse psychosocial consequences and lower the quality of life

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