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However, the included RCTs reported no cases of medullary thyroid carcinoma in either the tirzepatide or the control groups

It's also a long-term treatment experts often recommend staying on these medications to maintain the weight loss, similar to how we treat other chronic conditions

By systematically searching both PubMed, Embase, Cochrane, and Scopus and including only randomised controlled trials with at least 12 weeks of followup, we ensured methodological rigour and internal validity

Note : Both studies involved an initial dose escalation period and all study participants received lifestyle interventions (e.g., counselling on diet and physical activity)

This can help with weight-loss, but it can also lead to devastating gastrointestinal side effects

It hits three receptors simultaneously: GLP-1, GIP, and glucagon