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Reducing gastrointestinal side effects This is the primary driver

Trial populations, doses, and primary endpoints differ the cleanest read is per-trial, not per-class sweeping claims

[1] [2] For weight management, tirzepatide is available as Mounjaro under specific NICE criteria for adults with obesity or overweight with weight-related comorbidities

2020 Mar 30: Accessed 2021 Mar 25

Most plans require a documented body mass index (BMI) of 30 or higher, or 27 with obesity-related conditions like hypertension or type 2 diabetes
Did they happen to mention what lead to the increase