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Conclusion PWS is a complex disorder, and this syndromic obesity predisposes to an early risk of developing several health conditions as cardiometabolic diseases

Additionally, GIP triggers the RAC-alpha serine/threonine-protein kinase (AKT)/protein kinase B (PKB) signaling pathway, leading to phosphorylation and nuclear export of forkhead box protein O1 (Foxo1), thereby attenuating the expression of the proapoptotic BCL2-associated X (Bax) gene [86]

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