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In the SURPASS studies, the reduction of the systolic blood pressure was primarily mediated through weight loss [40, 54, 55]

[Google Scholar] 116.Anwer T, Sharma M, Khan G, Alam MF, Alam N, Ali MS, Alam MS

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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors a mechanism that sets it apart from approved agents such as semaglutide and tirzepatide

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