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The world of weight management and metabolic health has been transformed by GLP-1 agonists like semaglutide and tirzepatide

Results: GLP-1RA therapy significantly reduced HbA1c, body weight, and body fat percentage at 12 months

Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]

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[12] [13] Readers should note that direct head-to-head comparisons with GLP-1 monotherapy agents have not been conducted