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Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis

The FDA cleared orforglipron for chronic weight management in adults with obesity, or overweight with at least one weight-related comorbidity, based on the ATTAIN clinical program which showed placebo-adjusted weight loss of 7.5% to 11.2% in non-diabetics (ATTAIN-1) and 5.1% to 9.6% in diabetics at different doses, along with the expected glycaemic benefits (ATTAIN-2)

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Roberto Olivardia, a clinical psychologist and lecturer in the Department of Psychiatry at Harvard Medical School says that while appearance is factual, measurable, body image is personal and emotional a learned response based on each person's own history and experiences

Finally, a small study of 36 non-diabetic IBD patients treated with semaglutide or tirzepatide found no significant change in CRP and had insufficient data to evaluate FCP

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