what tier are glp 1 drugs MCT2D What are GLP-1s? | Mendinground
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On average the reported weight loss is between 3 and 5.5 lbs (1.5 to 2.5 kg)

Mol Endocrinol 2001

Note: animal studies indicate that high doses of DPP-4 inhibitors & GLP-1 agonists cause expansion of cells of the pancreatic ductal glands and can cause premalignant pancreatic intraepithelial lesions (PanIN) that have the potential to progress to pancreatic adenocarcinoma

doi: 10.4062/biomolther.2024.188

& Biessels, G

Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists: A State-of-the-Art Narrative Review