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After 12 months, 80% (8/10) of the POMC group and 45% of the LEPR group (5/11) achieved at least a 10% weight loss, with a mean hunger-score decrease of 27.1% in the POMC group and 43.7% in the LEPR group [16]

Hypoglycaemia concerns: Although uncommon with Mounjaro monotherapy, patients using the medication alongside other glucose-lowering agents (particularly insulin or sulphonylureas) may experience nocturnal hypoglycaemia, which can cause night-time awakening, sweating, and disrupted sleep architecture

Step one: verify your exact coverage status Do not assume your plan has changed

Clinical trials show headache rates of approximately 6-8% with diabetes doses and over 10% with higher weight-management doses

Weight loss drugs could make oral contraception less effective, MHRA warns: [accessed 20 March 2026] EMC (2024)

The evidence supports peptides as effective therapeutics when obtained through regulated channels, but emphasises the importance of medical supervision and avoiding unregulated sources for optimal safety outcomes