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Arachidonic acid can be converted into LTA4 (5,6-epoxide of arachidonic acid), and 4,5-LTA4 is a precursor of leukotrienes

Risk factors and systemic comorbidities HS is characterized by a complex and multifactorial etiology involving genetic predisposition, environmental triggers (i.e., stress), and behavioral factors (alcohol consumption, smoking), with a higher prevalence in women (ratio Female:Male 3:1) [22] (Fig

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