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Phase 2 data showed improvements in fasting glucose, HbA1c, insulin sensitivity, triglycerides, waist circumference, and liver fat content measured by MRI

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Psychiatry 45, 5463

Central GLP-1R activation in the hypothalamic arcuate nucleus and brainstem nucleus tractus solitarius modulates appetite circuits, reducing food intake through both immediate satiety signaling and longer-term feeding behavior regulation

Greater improvements in participants with exenatide plus dapagliflozin may be explained in part by their different, and potentially complementary, mechanisms of action and confirm other studies showing that combining these two agents may exert stronger beneficial effects than each drug alone, Karen Elkind-Hirsch, MSc, PhD, HCLD , scientific director of research at Womans Hospital Research Center in Baton Rouge, Louisiana, told Healio