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N Engl J Med 2023;389:514-526

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My solution to this problem was simple: 1 shot of 2.5-5 mg of Tirzepatide weekly combined with 1 shot of Retatrutide at 2-4 mg weekly By leveraging the appetite-suppressing effects of Tirzepatide to eliminate cravings and hunger, I was able to get the best of both worlds simultaneously

Boozer CN, Nasser JA, Heymsfield SB, Wang V, Chen G, Solomon JL

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The advantage of this work is that it partially addresses the prevailing general limitations encountered during the coupling of unprotected amino acids, including self-condensation (giving 6-membered diketopiperazines), sequential inversion, cyclisation, and over-reaction (Figure 4a)