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In hyperglycemic rats, SGLT2 inhibitor, canagliflozin, can also inhibit intestinal SGLT1, which is the primary transporter for glucose and galactose, to elevate plasma active GLP-1 level and reduce post-prandial glucose (108)
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The reality of the Ozempic Rebound underscores the importance of addressing the underlying causes that lead to weight gain to begin with

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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors