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Combination formulations may also have different pH optima for each component, forcing a compromise pH that may not be ideal for either peptide individually

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Furthermore, the secretome of hMSC-Ex-4 displayed an altered protein profile, including enhanced secretion of insulin-like growth factorbinding protein 2 (IGFBP2) and apolipoprotein M (APOM), both of which are implicated in metabolic regulation and may contribute to the therapeutic modulation of type 2 diabetes mellitus [18]

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