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[DOI] [PubMed] [Google Scholar] 24.Ruff CT, Baron M, Im K, ODonoghue ML, Fiedorek FT, Sabatine MS

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Recognising Plateau Patterns Recognising plateau patterns helps patients identify when theyre experiencing a temporary stall versus when they may need to adjust their approach

Consistent with this concept, up to 30% of individuals with PsO eventually develop PsA, a chronic inflammatory arthropathy affecting peripheral joints, entheses, and the axial skeleton ( Early PsA may display nonspecific musculoskeletal symptoms, such as inflammatory arthralgia or morning stiffness, even in the absence of overt synovitis or radiographic erosions ( At the pathogenic level, PsO and PsA share core inflammatory mechanisms driven by dysregulation of the IL17/IL23 and Tumour Necrosis Factor (TNF)- cytokine axes ( These immune pathways are closely intertwined with metabolic abnormalities, particularly obesity and adipose tissue dysfunction