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In the Pancreas: GLP-1 stimulates insulin secretion in a blood glucose dependentmanner hence decreasing B cell over function, enhancing Beta-cell survival rate, decreasing B- cell apoptosis and preserving B-Cell mass

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, et al

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

This treatment algorithm naturally selects people with longer disease duration and elevated cardiometabolic risk

No intermediate observations between baseline and week 104 were used in the analysis 59
after following this regimen for 12 weeks, average weight loss stood at 4.7% of initial body mass (5 kg as an absolute value) and increased to 6% (6.4 kg as an absolute value) when administered doses rose from 1.8 to 3 mg respectively, compared against a mere loss of about 2.2% body mass (which equates to 2.2 kg actual value) among those on placebo
